রবিবার, ৩ মার্চ, ২০১৩

1 in 3 Americans Have High Blood Pressure | Your Health Journal

HealthFrom Your Health Journal?..A great article from the Reporter Herald by Joyce Davis entitled 1 in 3 Americans have high blood pressure, but exercise and diet can help to reduce it. The article begins by stating hypertension / high blood pressure runs silent and deep in America. Roughly 68 million adults in the United States (about 1 in 3), have high blood pressure, increasing their risk for heart disease and stroke, the leading causes of death in our country. According to the American Heart Association, high blood pressure occurs when blood flow puts too much pressure or tension on the arteries which causes damage. Arteries that are blocked by cholesterol or have a buildup of plaque, can cause the heart to pump harder to get blood through. Eventually, the muscles and valves in the heart are damaged, leading to heart failure. Please visit the Reporter Herald web site (link provided below) to read the complete article. It was well written and very informative.?

From the article?..

Hypertension ? high blood pressure ? runs silent and deep in America.

An estimated 68 million adults in the United States, about 1 in 3, have high blood pressure, increasing their risk for heart disease and stroke, the leading causes of death in our country.

Known as a ?silent killer,? hypertension has no symptoms or warning signs, yet contributes to nearly 1,000 deaths per day. It?s a sneaky disease that runs counter to common belief ? someone with hypertension isn?t necessarily tense, nervous or hyper. Many are calm and cool, with no outward signs of a disease that can do serious damage to the heart, eyes, kidneys and brains.

High blood pressure, according to the American Heart Association (AHA), occurs when blood flow puts too much pressure or tension on the arteries, causing damage. Arteries that are blocked by cholesterol or have a buildup of plaque, can cause the heart to pump harder to get blood through. Eventually, the muscles and valves in the heart are damaged, leading to heart failure. The kidneys and brain may also be negatively affected when the vessels fail to supply adequate oxygen-rich blood.

Before such critical damage happens, however, some lifesaving steps can be taken by those with pre-hypertension. According to the Mayo Clinic, the period before high blood pressure goes full blown is the perfect time for prevention. During this pre-hypertension period, health-care experts advise having your blood pressure tested regularly and introducing healthy lifestyle changes.

Because there are no overt symptoms, it?s important to monitor your blood pressure either through doctor visits or with home checks. Staying in a healthy range ? below 120/80 ? can be as easy as making some simple changes to diet and activity.

A primary risk for hypertension is being overweight or obese. A greater body mass requires more blood to supply oxygen and nutrients to your tissues, increasing the force on artery walls. Family history also increases your chances of having pre-hypertension, as well as being older. Pre-hypertension is also more common in men than women, and in people who have a sedentary lifestyle.

Those with a diet high in sodium are also at risk. Too much sodium affects the way your body regulates blood pressure, so reducing the amount of salt you consume is an easy, positive way to prevent the disease.

To read the full article?..Click here

Source: http://www.lensaunders.com/wp/1-in-3-americans-have-high-blood-pressure/

liquidmetal gsa scandal kelis dick clark dies ibogaine jamie moyer bone cancer

The Bachelor Women Tell All Preview: All About Tierra!

Source: http://www.thehollywoodgossip.com/2013/03/the-bachelor-women-tell-all-preview-all-about-tierra/

record store day 2012 detroit red wings jose canseco zimmerman derek fisher lyrid meteor shower hippocrates

শনিবার, ২ মার্চ, ২০১৩

Mich. governor declares Detroit fiscal emergency

Gov. Rick Snyder of Michigan on Friday declared a fiscal state of emergency in Detroit in a move that could lead to the appointment of a financial manager who could file for the largest municipal bankruptcy ever.

Snyder's decision allows the city a 10-day grace period to formulate a plan to fix its finances before the governor reconsiders appointing an emergency manager who would likely drastically reduce services.

The Republican governor said he had identified a top candidate for the position, but he declined to name the person.

"I believe it's appropriate to declare the city of Detroit in financial emergency," Snyder said at a forum in Detroit.

Snyder said he agreed with a Feb. 19 report by a six-member team of experts that concluded Michigan's largest city is in dire financial shape and a plan put in place last April to aid Detroit was not sufficiently working.

The expert team Snyder assembled in December did not officially recommend the appointment of an emergency financial manager, leaving that decision up to the governor.

Detroit officials now have 10 days to request a hearing with the governor about his determination.

After the hearing or the expiration of the 10 days in the case of no hearing, the governor confirms or revokes his determination. A confirmation will assign management of Detroit's fiscal emergency to a Local Emergency Financial Assistance Loan Board composed of three state officials, including the treasurer, who are all Snyder appointees. That board would also appoint a manager for the city, under the current state law.

Detroit officials also will have the ability to appeal the fiscal emergency determination in state court. But that move would likely not delay the appointment of a manager, who could ultimately recommend the city file for bankruptcy. A Chapter 9 municipal bankruptcy by Detroit would be the largest ever in the United States.

Detroit has faced the steepest population decline of any American city in recent decades. Once the fifth largest U.S. city that shone as the birthplace of the U.S. automotive industry and Motown music, it now ranks 18th with about 700,000 people - after suffering a 25 percent decline in population between 2000 and 2010.

With the exodus of residents and jobs as the auto industry contracted, the city has suffered from declining tax revenue and rising crime while saddled with the infrastructure and labor costs of a bygone era.

An emergency financial manager for Detroit would have the power to develop a financial plan, revise or reject budgets, consolidate departments, enter into service contracts with other local governments, reduce or eliminate the salaries of elected officials, sell eligible city assets, lay off workers and renegotiate labor contracts. The manager cannot abrogate labor contracts or impose taxes without voter approval under the state's 1990 law.

A new Michigan law that takes effect March 28 will allow existing emergency financial managers to remain in place and will give them additional powers, including the ability to revise or terminate collective bargaining agreements.

Reuters contributed to this report.

Source: http://www.nbcnews.com/business/economywatch/michigans-governor-declares-detroit-state-financial-emergency-1C8638601

Olympic Medal Count 2012 Olympics 2012 Olympic Schedule 2012 NBC Olympics NBC Olympics schedule 2012 Olympics Chad Everett

Exclusive: Glencore bartered with firm linked to Iran nuclear program

UNITED NATIONS (Reuters) - Commodities giant Glencore supplied thousands of tons of alumina to an Iranian firm that has provided aluminum to Iran's nuclear program, intelligence and diplomatic sources told Reuters.

The previously undisclosed barter arrangement between Glencore, the world's biggest commodities trader, and the Iranian Aluminum Company (Iralco) illustrates how difficult it is for Western powers to curb Iran's ability to trade with the rest of the world. Even as the West imposes stringent restrictions on banks that do business with Iran, United Nations diplomats say that Tehran keeps finding new ways to do business with willing partners.

Reuters first learned about Glencore's barter deal with Iralco, and an aluminum supply contract that Iralco had with Iran Centrifuge Technology Co (TESA), from a Western diplomatic source in early November. That was about six weeks before the European Union's December 2012 decision to levy sanctions on Iralco for supplying aluminum metal to TESA, which is a subsidiary of the Atomic Energy Organization of Iran (AEOI).

The source showed Reuters a Western intelligence report concerning Glencore's arrangement with Iralco. It described how Baar, Switzerland-based Glencore provided Iralco with thousands of tons of alumina last year in exchange for a lesser amount of aluminum metal. The report's authenticity was confirmed by U.N. diplomats.

It is not known whether any of the aluminum produced by Iralco from Glencore's alumina raw material actually ended up with TESA. As part of AEOI, TESA has been subject to U.N. sanctions in place since 2006.

In a statement to Reuters, Glencore said it first learned about the TESA-Iralco relationship in December and immediately "ceased transactions" with Iralco. It said its last actual trade as part of the barter arrangement was in October 2012, two months before the EU move.

Glencore acknowledged that it did sign the barter deal with Iralco in August 2011, saying it was perfectly legal and denied any wrongdoing by the firm or attempts to help Iran bypass sanctions. It declined to provide details about the barter deal, the value of which is unclear.

Iralco did not respond to an emailed request for a comment. Iran's U.N. mission said it was not in a position to comment.

Iran denies allegations by Western powers and their allies that it is seeking atomic weapons and has refused to stop enriching uranium. As a result, in addition to four rounds of U.N. sanctions, Iran has faced much tougher U.S. and EU measures, specifically targeting its financial and energy sectors.

ALUMINUM TUBES

Aluminum can be used to make aluminum tubes for uranium enrichment gas centrifuges, though most newer gas centrifuges are made of a carbon composite material. Aluminum is also used in everything from cars to aircraft, buildings and cans.

Glencore had supplied Iralco with about five tons of alumina for every ton of aluminum that Glencore received in return, according to the intelligence report. Given that on average it takes only about two tons of alumina to produce one ton of aluminum, the barter deal may have left Iralco with more aluminum after processing the alumina than it supplied to Glencore.

Iralco covered costs inside Iran, while all activity involving foreign currency payments was covered by Glencore, including shipping costs and insurance, according to the intelligence report.

In its statement, Glencore said: "Glencore complies with applicable laws and regulations, including applicable sanctions. We closely monitor all new legal developments to ensure that we continue to be in compliance with applicable laws and regulations, including applicable sanctions."

The company said that alumina and aluminum metal were not prohibited commodities under the sanctions, and that bartering is one of the oldest and most transparent forms of transaction and an accepted method in the metals business.

Swiss authorities said they saw no evidence of U.N. or Swiss sanctions violations by Glencore. Iralco is not under U.S. or U.N. sanctions.

The intelligence report described the Glencore deal as a good way for Tehran to get around global financial restrictions, though it did not say that Glencore violated sanctions.

OFF THE GRID

A U.N. expert panel has repeatedly reported to the U.N. Security Council that Iran has learned to dodge sanctions with the aid of shell companies and intermediaries and a small group of friendly countries. But it has become extremely difficult for any Iranian firm to make or receive payments abroad due to sanctions on Iranian banks - including the central bank - and the barring of Iran from the international banking clearinghouse SWIFT.

The appeal of barter deals is that because payments are made in goods rather than money, transactions are kept off the international financial grid and are less likely to be identified by governments trying to curb Iran's nuclear program.

"From Iran's point of view, the business offered through the exchange agreement (with Glencore) offers a model that can be replicated for trade in a range of commodities that it requires, by reaching similar deals with other foreign companies that have commercial interests but are reluctant to deal with Iran in the current circumstances," the intelligence report said. "Each side benefits from the trade agreement, while risks of exposure through inevitable contact with third parties are dramatically reduced."

The EU said it imposed sanctions on Iralco in December because the company was allegedly "assisting designated entities to violate the provisions of U.N. and EU sanctions on Iran and is directly supporting Iran's proliferation sensitive nuclear activities." The EU said that Iralco had a contract to supply aluminum to Iran's centrifuge firm TESA from the middle of 2012, according to the official EU bulletin on the sanctions.

A source close to Glencore said that Iralco received its last alumina shipment from Glencore in September while Glencore received its last delivery of aluminum from Iralco in October.

The source declined to comment when asked if the firm continued to do other business with Iran. Glencore announced an end to its fuel sales to Iran in January 2010 to avoid breaching U.S. sanctions.

CONTROVERSY

The U.S. Treasury Department declined to comment specifically on Glencore's dealings with Iralco, though a Treasury official told Reuters anyone providing alumina to Iran can face U.S. sanctions under new rules taking effect on July 1.

Swiss companies have been bound by U.N. sanctions ever since Switzerland joined the United Nations in 2002. While Switzerland implemented sanctions on Libya and Syria, it has reasserted its traditional neutrality over Iran and opted not to adopt some of the more stringent measures passed by the EU and the United States.

Glencore has been involved in controversies before. It was founded as ?Marc Rich & Co' in 1974 by Marc Rich, who was charged by the U.S. authorities in the early 1980s with evading taxes and selling oil to Iran during the 1979-81 hostage crisis. He fled to Switzerland where he lived as a fugitive for 17 years before being pardoned by then U.S. President Bill Clinton just before he left office in 2001. After a bet on the zinc market failed, the firm struggled badly and Rich eventually sold it through a management buyout in 1994.

(Additional reporting by Emma Farge in Geneva; Editing by Martin Howell and Jean Yoon)

Source: http://news.yahoo.com/exclusive-glencore-bartered-firm-linked-iran-nuclear-program-060856166--finance.html

selena lamichael james lamichael james derrick rose acl earthquake los angeles unemployment

শুক্রবার, ১ মার্চ, ২০১৩

Metal ions regulate terpenoid metabolism in insects

Feb. 28, 2013 ? Max Planck scientists in Jena, Germany, have discovered an unusual regulation of enzymes that catalyze chain elongation in an important secondary metabolism, the terpenoid pathway. In the horseradish leaf beetle Phaedon cochleariae a single enzyme can trigger the production of two completely different substances depending on whether it is regulated by cobalt, manganese or magnesium ions: iridoids, which are defensive substances the larvae use to repel predators, or juvenile hormones, which control insect's development. Insects unlike plants do not have a large arsenal of the proteins called isoprenyl diphosphate synthases. Therefore they may have developed another efficient option to channel metabolites into the different directions of terpenoid metabolism by using metal ions for control.

Natural products: 40,000 terpenes

Apart from the primary metabolism which produces substances that ensure the survival of the cells, there are additional biosynthetic pathways in all organisms. Their products may be less important for a single cell, but they can nevertheless be essential for the whole organism. These pathways are summarized as secondary metabolism. One of them is the terpenoid pathway: with more than 40,000 different known structures it generates one of the largest classes of natural products. Terpenoid molecules have diverse functions and can act as components in molecular signaling pathways, as toxins, fragrances or hormones.

The basic unit of all terpenes is a simple molecule containing five carbon atoms that can be joined to chains of different length. There are monoterpenes (C10 units, 2 x C5), sesquiterpenes (C15, 3 x C5), and even polymers, such as natural rubber, which comprises several hundred C5 units. Special enzymes mediate chain elongation. These enzymes have attracted the curiosity of scientists at the Max Planck Institute for Chemical Ecology, Jena, and the Leibniz Institute for Plant Biochemistry in Halle. They studied mechanistic alternatives of how chain elongation is regulated.

Metal ions instead of specialized enzymes

Enzymes involved in chain elongation belong to the group of isoprenyl diphosphate synthases. Such an enzyme was isolated from larvae of the horseradish leaf beetle Phaedon cochleariae. It raised the interest of Antje Burse, project group leader in the Department of Bioorganic Chemistry at the Max Planck Institute for Chemical Ecology.

Experiments with larvae in which the enzyme encoding gene was silenced showed that the protein was involved in the formation of the C10 monoterpene chrysomelidial that larvae produce to defend themselves against predators. The larvae accumulate this monoterpene in special glands and release it as a defensive secretion when they are attacked by their enemies, such as ants.

However, surprising results emerged after comprehensive biochemical characterization of the enzyme. "After we had conducted an in vitro analysis of the protein, including measurements of product formation in the presence of different metal ions as co-factors, we were surprised to discover that only geranyl diphosphate (C10), a precursor for the defensive substance chrysomelidial, was produced after addition of cobalt and manganese ions. On the other hand, adding magnesium ions resulted in the formation of farnesyl diphosphate (C15), a potential precursor for juvenile hormones, which is 5 carbon atoms longer," says the scientist. All three metals were found in larval tissue, leading to the assumption that enzyme catalysis is directed by the different metal co-factors in the larvae, whichever is predominant in amount: Towards toxin or hormone ? physiologically a major difference.

Sequence comparisons cannot replace a thorough biochemical analysis

How the different metal ions modify the product range of the enzyme is still unclear. It is very likely that the varying atomic radii of the metal ions involved in the catalysis effect changes in the spatial structure of the enzyme, which prevent or allow the admission of a third C5 unit and hence result in the production of C10 or C15 molecules.

"Our experiments provide two important findings," says Wilhelm Boland, director at the Max Planck Institute. "First, the directing influence of metal ions on the product formation of isoprenyl diphosphate synthases is a novel "control element" in the regulation of the terpene metabolism which should be included in future experimental settings. And secondly: The diversity of terpenoid molecules cannot be attributed solely to the broad substrate specificity of some enzymes in the last steps of the metabolic pathway, but is in fact already inherent in early biosynthetic steps." Nature continues to provide interesting answers to the question how organisms manage to produce tens of thousands of different secondary metabolites.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Max Planck Institute for Chemical Ecology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Frick, R. Nagel, A. Schmidt, R. R. Bodemann, P. Rahfeld, G. Pauls, W. Brandt, J. Gershenzon, W. Boland, A. Burse. Metal ions control product specificity of isoprenyl diphosphate synthases in the insect terpenoid pathway. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1221489110

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/ZoYNlp3uNmI/130228103440.htm

azerbaijan ryan howard ps i love you ray charles cheney heart transplant weather san diego unitarian

A plane may not be the place for the Harlem Shake

COLORADO SPRINGS, Colo. (AP) ? The latest craze to sweep the Internet is bringing college students the wrong kind of attention ? from the Federal Aviation Administration.

During a flight from Colorado Springs to San Diego, a group of students started the Harlem Shake, a dance to a song of the same name.

In the suddenly popular YouTube videos, one person starts dancing, then the video cuts to a large group of people dancing, many in costume.

Matt Zelin, a sophomore, told the Colorado College newspaper, The Catalyst (http://bit.ly/13qgjK2 ), he asked a flight attendant for permission beforehand.

FAA spokesman Allen Kenitzer said Thursday they're looking at what phase the flight was in during the dance in the aisles.

Frontier Airlines says the seatbelt sign was off and safety measures were followed.

Source: http://news.yahoo.com/shake-plane-dance-craze-brings-faa-inquiry-195833450.html

2012 dunk contest edgar vs henderson berkshire hathaway ufc 144 james jones james jones aladdin

Mobile World Congress 2013: best of show

Mobile World Congress 2013 best of show

Another Mobile World Congress has come and gone. While we weren't treated to a mountain of device launches, as seen in previous years, we definitely all came away with some favorites. LG outed a few handsets, HTC's One made its first public appearance and Firefox OS made a grand entrance with additions to the new platform from a few different handset makers. And, on the wireless side, we were treated to what has to have been the biggest NFC love fest we've ever witnessed. Follow on past the break to check out some of our favorites from this year's MWC, then weigh in and let us know what you think about the show.

Filed under: , , , , , , , ,

Comments

Source: http://www.engadget.com/2013/02/28/mobile-world-congress-2013-best-of-show/

Super Bowl Winners what time does the superbowl start Kaepernick Tattoos superbowl time what time is the super bowl world war z groundhog day